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KMID : 1101320040360020205
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Korean Journal of Clinical Laboratory Science
2004 Volume.36 No. 2 p.205 ~ p.209
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Analysis of Cytogenetics Diagnosis: form 30 Years Experience at Kwangju Christian Hospital
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Kim Yoon-Sik
Back Hae-Kyong
Lee Sang-Ho
Shin Jin-Ho
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Abstract
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This study was carried out to review and evaluate a total of 2,463 cases of human chromosomal analysis at Kwangju Christian Hospital from 1974 to 2004. We collected 2.0-3.0ml of human peripheral blood in heparized bottle. Then, we cultured it for 72 hours. We performed GTG-banding and chromosomal kayotyping analysis by Cytovision kayotyping system. Abnormal karyotypes were observed in 30.5% of the total cases (750/2,463). Autosome and sex chromosome anomalies were observed in 25.8% (635/2,463) and 4.7% (115/2,463) respectively. In a total of 2463 cases, there were 522 (22.4%) cases of Down's syndrome karyotype, and 67 (2.7%) cases of Turner syndrome. In conclusion, Down's syndrome has decreased after the end of the 1990s, but other (Turner syndrome et al.) chromosomal abnormal cases haven't decreased after the1970s.
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KEYWORD
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Chromosomal kayotyping, Chromosomal abnormal, Down's syndrome, Turner syndrome.
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